Previous research has suggested that nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, might help in preventing dementia.

However, a new study published online in the journal, Neurology, suggests that NSAIDs may only delay, rather than prevent, the onset of dementia.

Researchers from the University of Washington in Seattle analyzed the relationship between prior NSAID use and a diagnosis of dementia and Alzheimer disease (AD) among 2,736 adults aged 65 or older who were dementia-free. The study participants were followed every two years for up to 2 years to identify the development of dementia or AD. Pharmacy records revealed that 351 of the study participants had a history of heavy NSAID use at the time of enrollment in the study. An additional 107 became heavy users during the follow-up period. Among the participants, 476 individuals developed dementia, 356 of whom were diagnosed with AD. The researchers found that, rather than protecting against AD, heavy NSAID use increased the incidence of dementia and AD.

The researchers speculate that their findings differ from previous reports because those studies included younger participants. They suggest that NSAID use may delay the onset of dementia, resulting in an increased number of AD diagnoses in late old age. However, these conclusions require further research and, for now, NSAIDs should not be taken for the prevention of dementia or AD.

Source:

Neurology. Published online before print April 22, 2009.