If you are currently being treated with any of the following medications, you should not use DHEA without first talking to your healthcare provider.

AZT (Zidovudine)
In a laboratory study, DHEA enhanced the effectiveness of an HIV medication known as AZT. However, scientific studies in humans are needed before DHEA can be used for this purpose in people.

Barbiturates
Animal studies suggest that DHEA may increase the effects of barbiturates, a class of medications often used to treat sleep disorders including butabarbital, mephobarbital, pentobarbital, and phenobarbital. However, scientific studies in humans are needed before it is known whether this same effect occurs in people and whether it is safe for DHEA and barbiturates to be used together.

Cisplatin
An animal study indicates that DHEA may increase the effectiveness of an anti-cancer medication known as cisplatin; further studies are needed to know if this effect applies to people.

Steroids
Laboratory studies suggest that DHEA may increase the effects of prednisolone, a steroid medication used to treat inflammation and other disorders. Additional research is needed to determine if this effect applies to people.

Estrogen
It is possible that DHEA may influence the level of estrogen in the body. For this reason, some women on estrogen replacement therapy may need to adjust their dosage. This should be discussed with your healthcare provider.