|
New territory,
unexplored or only sketchily mapped, lies ahead. As gerontologists
isolate and characterize more and more longevity- and aging-related
genes in laboratory animals, insights into genes and gene products
important in human aging will emerge. Comparable human genes will
be identified and mapped to chromosomes.
This information
will be useful in designing both genetic and non-genetic interventions
to slow or even reverse some aging-related changes. Already, for
example, a study by Helen Blau of Stanford University has shown
that muscle cells can be genetically modified and injected into
muscle where they will produce and secrete human growth hormone.
Non-genetic strategies will include the development of interventions
to reduce damage to cellular components, such as proteins, nucleic
acids, and lipids.
Normal aging
will be more closely defined. For instance, at NIA's Gerontology
Research Center, the behavior of the cells that line blood vessels
during aging is now providing clues to the stiffening of blood vessels
that occurs with age as well as insights into vascular disease.
As key biomarkers of aging are identified, researchers will be able
to use them to test interventions to slow aging. Studies will begin
to delve more deeply into differences in aging between the sexes
and among ethnic groups.
In short,
gerontologists will be charting the paths and intersections of genetic,
biochemical, and physiologic aging. What they find will reveal some
of the secrets of aging. It may lead to extended life spans. It
will very certainly contribute to better health, less disability,
and more independence in the second fifty years of life.
For More Information:
National Institute
on Aging
Public Information Office
Building 31, Room 5C27
Bethesda, MD 20892
301-496-1752
|
