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J.A.J. Schmitt1, E. Hogervorst2 , E.F.P.M. Vuurman1, J. Jolles1, W.J.
Riedel1
1. Experimental Psychopharmacology Unit, Brain and Behaviour Institute,
Universiteit Maastricht, Maastricht, The Netherlands ; 2. Department of
Pharmacology and Radcliffe Infirmary Trust, OPTIMA, University of Oxford,
Oxford, United Kingdom. Address correspondence: Jeroen A.J. Schmitt, MSc
PhD, Experimental Psychopharmacology Unit, Dept. of Psychiatry & Neuropsychology
(DRT10), Universiteit Maastricht, PO Box 616, 6200 MD Maastricht, The
Netherlands, Telephone : +31 43 3871449, Fax : +31 43 3884096, E-mail
: j.schmitt@np.unimaas.nl
Abstract: The putative beneficial effects of caffeine on cognitive performance
may vary between ages. The acute cognitive effects of 100 g caffeine on
memory functions and focussed attention were investigated in sixteen middle-aged
(45-60 years) and fourteen elderly (60-75 years) healthy men and women
according to a cross-over design. Caffeine did not affect short-term memory
span or speed, long-term memory retrieval functions or focussed attention.
It is proposed that in middle-aged and elderly subjects cognitive effects
may occur predominantly at higher caffeine dosages.
Keywords : Caffeine, cognition, memory, attention, age, caffeine-withdrawal
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