C. MONARQUE-FAVARD*, I. GARCIA**, H. ABIDI***, E. BANNIER**, J. RIVIERE**, J. DRAI**, M. BONNEFOY*

*Service de Gériatrie, **Laboratoire de Biochimie2, ***Service d'Hygiène et d'Epidémiologie, Centre hospitalier Lyon Sud, F. 69495 Pierre-Bénite Cedex France.
Tel : 04 78 86 15 80. Fax : 04 78 86 57 27 - e.mail : marc.bonnefoy@chu-lyon.fr

Protein-energy malnutrition is common in the elderly. The relationship between protein-energy malnutrition and lipid status remains uncertain and few studies are available.The aim of this study was to evaluate the lipid status of malnourished elderly subjects recently hospitalized in a geriatric medical care unit. Classical parameters such as total cholesterol, HDL cholesterol, apoproteins A1 et B, vitamins A and E were measured. Particular attention was given to other parameters such as fatty acids. The studied population included 86 elderly subjects. They were divided into two groups, according to serum albumin (alb) and Body Mass Index (BMI). Fifty patients aged 81.5 ± 7.3 years were considered to be well-nourished (WN) with albumin = 35g/l and BMI = 21kg/m2. Thirty six patients aged 84.1 ± 6.6 years were considered to be malnourished (MN) with albumin < 35g/l and BMI < 21kg/m2. Our main findings shown significant decrease in all classical lipid parameters : total cholesterol (p< 0.001), HDL cholesterol (p< 0.005), apoproteins A1 (p< 0.001) and B (p< 0.001) in the malnourished group. We found an increase in the rate of v9 fatty acids (p< 0.001 for the oleic acid ; p< 0.05 for the eicosatrienoic acid) and also an increase in the triene/tetraene ratio (p< 0.05) as a result of malnutrition. Conclusion : Protein-energy malnutrition is accompanied by lipid status alterations.

Keywords: Elderly people, protein-energy malnutrition, cholesterol, lipid status, essential fatty acids.