The American Federation for Aging Research

Is there a genetic clock for aging?
Other Resources

References

1- Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 1992; 89: 10114-8.

2- Greider CW, Blackburn EH. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 1989; 337: 331-7.

3- Lee, H-W, Blasco MA, Gottlieb GJ, Greider CW, DePinho RA. Essential role of mouse telomerase in highly proliferative organs. Nature 1998; 392; 569-574.

4- Herbert B-S, Pitts AE, Baker SI, Hamilton SE, Wright WE, Shay JW, Corey DR. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci 1999; 96: 14276-81.

5- Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE, Weinrich SL, Shay JW. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011-5.

6- Harley CB. Human ageing and telomeres. Ciba Found Symp 1997; 211: 129-39.

7- Chang E, Harley CB. Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci USA 1995; 92: 11190-4.

8- Aikata H, Takaishi H, Kawakami Y, Takahashi S, Kitamoto M, Nakanishi T, Nakamura Y, Shimamoto F, Kajiyama G, Ide T. Telomere reduction in human liver tissues with age and chronic inflammation. Exp Cell Res 2000; 256: 578-82.

9- Melk A, Ramassar V, Helms LM, Moore R, Rayner D, Solez K, Halloran PF. Telomere shortening in kidneys with age. J Am Soc Nephrol 2000; 11: 444-53.

10- Miller RA. Telomere diminution as a cause of immune failure in old age: an unfashionable demurral. Biochem Soc Trans 2000; 28: 241-5.

11- Aviv A, Aviv H. Telomeres, hidden mosaicism, loss of heterozygosity, and complex genetic traits. Hum Genet 1998; 103: 2-4.

12- Buys CHCM. Telomeres, telomerase, and cancer. N Engl J Med 2000; 342: 1282-3.

13- Shay JW. Aging and cancer: are telomeres and telomerase the connection? Mol Med Today 1995; 1: 378-84.

14- Kim NW. Clinical implications of telomerase in cancer. Eur J Cancer 1997; 33: 781-6.

15- Davis AJ, Siu LL. Telomerase: therapeutic potential in cancer. Cancer Invest 2000; 18: 269-77.

16- Hiyama E, Hiyama K, Yokoyama T, Matsuura Y, Piatyszek MA, Shay JW. Correlating telomerase activity levels with human neuroblastoma outcome. Nat Med 1995; 1: 249-55.

17- Morin GB. The implications of telomerase biochemistry for human disease. Eur J Cancer 1997; 33: 750-60.

18- Sharma A, Raymond E, Soda h, Sun D, Hilsenbeck SG, Sharma A, Izbicka E, Windle B, Von Hoff DD. Preclinical and clinical strategies for development of telomerase and telomere inhibitors. Ann Oncol 1997; 8: 1063-74.

19- Lavelle R, Riou J, Loaui A, Mailliet P. Telomerase: a therapeutic target for the third millenium? Crit Rev Oncol Hematol 2000; 34: 111-26.

20- Buys CHCM. Telomeres, telomerase, and cancer. N Engl J Med 2000; 342: 1282-3.

21- Prescott JC, Blackburn EH. Telomerase: Dr. Jekyll or Mr. Hyde? Curr Opin Genet Dev 1999; 9: 368-73.

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