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Are there new vaccines and other immunological strategies that may help us ward off the disease of aging?
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Selected Article References
 
Candore G, Di Lorenzo G, Mansueto P, Melluso M, Frada G, Li Vecchi M, Esposito Pellitteri M, Drago A, Di Salvo A, Caruso C. Prevalence of organ-specific and non organ-specific autoantibodies in healthy centenarians. Mech Ageing Dev 1997; 94: 183-909.

Chandra RK. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 1992; 340: 1124-7.

Corridan BM, O'Donoghue M, Hughes DA, Morrissey PA. Low-dose supplementation with lycopene or beta-carotene does not enhance cell-mediated immunity in healthy free-living elderly humans. Eur J Clin Nutr 2001; 55; 627-35.

Enioutina EY, Visic VD, Daynes RA. Enhancement of common mucosal immunity in aged mice following their supplementation with various antioxidants. Vaccine 2000; 18: 2381-93.

Gasparini R, Pozzi T, Montomoli E, Fragapane E, Senatore F, Minutello M, Podda A. Increased immunogenicity of the MF-59-adjuvanted influenza vaccine compared to a conventional subunit vaccine in elderly subjects. Eur J Epidemiol 2001; 17: 135-40.

Ginaldi L, De Martinis M, D'Ostilio A, Marini L, Loreto MF, Quaglino D. The immune system in the elderly: III. Innate immunity. Immunol Res 1999; 20: 117-26.

Gonzalez-Gay MA, Hajeer AH, Dababneh A, Makki R, Garcia-Porrua C, Thomson W, Ollier W. Seronegative rheumatoid arthritis in elderly and polymyalgia rheumatica have similar patterns of HLA association. J Rheumatol 2001; 28: 122-5.

Goronzy JJ, Fulbright JW, Crowson CS, Poland GA, O'Fallon WM, Weyand CM. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol 2001; 75: 12182-7.

Grubeck-Lowenstein B. Changes in the aging immune system. Biologicals 1997; 25: 205-8.

Khorram O, Garthwaite M, Golos T. The influence of aging and sex hormones on expression of growth hormone-releasing hormone in the human immune system. J Clin Endocrinol Metab 2001; 86: 3157-61.

Leder K, Weller PF, Wilson ME. Travel vaccines and elderly persons: review of vaccines available in the United States. Clin Infect Dis 2001; 33: 1553-66.

Lesourd B, Mazari L. Nutrition and immunity in the elderly. Proc Nutr Soc 1999; 58: 685-95.

Lord JM, Butcher S, Kilampali V, Lascelles D, Salmon M. Neutrophil ageing and immunosenescence. Mech Ageing Dev 2001; 122: 1521-35.

Philip, RB. Bystanders or bad seeds? Many autoimmune-target cells may be transforming to cancer and signaling "danger" to the immune system. Autoimmunity 2001; 33: 121-34.

Rubins JB, Janoff EN. Pneumococcal disease in the elderly: what is preventing vaccine efficacy? Drugs Aging 2001; 18: 305-11.

Santos MS, Leka LS, Ribaya-Mercado RM, Meydani M, Hennekens CH, Gaziano JM, Meydani SN. Short- and long-term beta-carotene supplementation do not influence T cell-mediated immunity in healthy elderly persons. Am J Clin Nutr 1997; 66: 917-24.

Tamir A, Eisenbrain MD, Garcia GG, Miller RA. Age-dependent alterations in the assembly of signal transduction complexes at the site of T cell/APC interaction. J Immunol 2000; 165: 1243-51.

Weng NP. Palmer LD, Levine BL, Lane HC, June CH, Hodes RJ. Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging. Immunol Rev 1997; 160: 43-54.

Yang D, Miller RA. Cluster formation by protein kinase Ctheta during murine T cell activation: effect of age. Cell Immunol 1999; 195: 28-36.

Young MR, Kolestiak K, Achille NJ, Gonzalez E, Liu SW, Wrone-Smith T, Lathers DM. Impact of aging on immune modulation by tumor. Cancer Immunol Immunother 2001; 50: 315-20.



 
 
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