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In April of 1998, scientists from the University of Colorado School of
Medicine reported that they had successfully used cloning as the first
step in the successful treatment of an animal form of Parkinson's disease.
Led by Dr. Curt Freed, the researchers used the same technique used to
create Dolly to create cow embryos. After the cow embryos had gestated
six to seven, the scientists isolated nerve cells with the capacity to
produce dopamine, the missing chemical in the brains of patients with
Parkinson's disease. The nerve cells were then transplanted into the brains
of rats with the rat form of Parkinson's disease. The rats' neurological
symptoms improved after the nerve cell transplants. Nerve cell transplants
of fetal human cells have been used with variable success in human patients
with Parkinson's disease, but this technique, if applicable to humans,
holds some promise for greater success.
Another early step in the possible use of cloning to treat human disease
has been reported by the company that helped to create Dolly. This group
created genetically engineered cloned pigs. Pigs are potentially good
sources of organs for human transplantation needs (indeed, pig valves
are used routinely to replace certain damaged human heart valves). The
scientists are hopeful that their ability to alter the pigs' genetic structure
and yet still produce healthy piglets is a first step in producing pigs
whose organs, when transplanted, are less likely to be rejected by the
human immune system. Though this work is also quite preliminary, it also
holds future promise.
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