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The Human Genome Project is a massive scientific undertaking sponsored
by the U.S. Department of Energy and the National Institutes of Health.
Begun in 1990, this ambitious initiative seeks to identify all the genes
humans possess. At its inception, the project was expected to take 15
years; advances in technology have reduced that to 13 years, with an expected
completion date in 2003.
The Human Genome Project intends to identify all of the approximately
30-40,000 genes that make up the human genome and determine the precise
makeup of each of those genes. Genes carry the information needed by our
cells to make our proteins, which in turn carry out the necessary functions
of cells, organs and our bodies. Our genes determine our hair and eye
color, some of the diseases to which we might fall prey, and it is believed,
to some extent our life span. One long-term outcome of mapping the entire
human genome will be to know the function of each human gene.
The project has not been without controversy. Two separate groups of
scientists worked to accomplish the sequencing or unraveling of the human
genome. Some of those working on the project were funded by the National
Institutes of Health (NIH) and the Department of Energy, under the direction
of Dr. Francis Collins, head of the NIH's Human Genome Research Institute.
At the same time, a private biotechnology company, Celera Genomics, under
CEO Dr. Craig Ventner was also successfully decoding the mysteries of
human heredity. The ongoing professional rivalry between the two groups
of scientists was largely laid to rest in the spring of 2000, paving the
way for a joint announcement on June 26, 2000, that the human genome had
been successfully sequenced. The announcement referred to the complete
sequencing of about 90% of the genes that appear on human chromosomes.
The refinement of the sequencing, with the remaining 10% of the genes
fully identified, should be accomplished by 2003.
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