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What does research on other animals and organisms tell us about the human aging process?
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Selected References
 


Arking R, Burde V, Graves K, Hari R, Feldman E, Zeevi A, Soliman S, Saraiya A, Buck S, Vettraino J, Sathrasala K, Wehr N, Levine RL. Forward and reverse selection for longevity in Drosophila is characterized by alteration of antioxidant gene expression and oxidative damage patterns. Exp Gerontol 2000; 35: 167-85.

Calingasan NY, Gibson GE. Dietary restriction attenuates the neuronal loss, induction of heme oxygenase-1 and blood brain barrier breakdown induced by impaired oxidative metabolism. Brain Res 2000; 885: 62-9.

Calleja FM, Nivard MJ, Eeken JC. Induced mutagenic effects in the nucleotide excision repair deficient Drosophila mutant mus201(D1), expressing a truncated XPG protein. Mutat Res 2110; 461: 219-288.

Grant CM, MacIver FH, Dawes IW. Mitochondrial function is required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae. FEBS Lett 1997; 410: 219-22.

Guenette SY, Tanzi RE. Progress toward valid transgenic mouse models for Alzheimer's disease. Neurobiol Aging 1999; 20: 201-11.

Horiki S, Miyauchi-Hashimoto H, Tanaka K, Nikaido O, Horio T. Protective effects of sunscreening agents on photocarcinogenesis, photoaging, and DNA damage in XPA gene knockout mice. Arch Dermatol Res 2000; 292: 511-8.

Hsiao K. Transgenic mice expressing Alzheimer precursor proteins. Exp Gerontol 1998; 33: 883-9.

Hutchinson JN, Muller WJ. Transgenic mouse models of human breast cancer. Oncogene 2000; 19: 6130-7.

Jamieson DJ. Oxidative stress responses of the yeast Saccharomyces cerevisiae. Yeast 1998; 14: 1511-27.

Jazwinski SM. Metabolic control and ageing. Trends Genet 2000;16:506-11.

Jiang JC, Jaruga E, Repnevskaya MV, Jazwinski SM. An intervention resembling caloric restriction prolongs life span and retards aging in yeast. FASEB J 2000; 14:2135-7.

Kakuo S, Asaoka K, Ide T. Human is a unique species among primates in terms of telomere length. Biochem Biophys Res Comm 1999; 263: 308-14.

Koback-Larsen M, Thorup I, Diederichsen A, Fenger C, Hoitinga MR. Review of colorectal cancer and its metastases in rodent models: comparative aspects with those in humans. Comp Med 2000; 50: 16-26.

Lane MA. Nonhuman primate models in biogerontology. Exp Gerontol 2000; 35: 533-41.

Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 2000; 289: 2126-8.

Luikenhuis S, Perrone G, Dawes IW, Grant CM. The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen species. Mol Biol Cell 1998; 9: 1081-91.

Miskin R, Masos T, Yahav S, Shinder D, Globerson A. AlphaMUPA mice: a transgenic model for increased life span. Neurobiol Aging 1999; 20: 555-64.

Moechars D, Dewachter I, Lorent K, Reverse D, Bakelandt V, Naidu A, Tesseur I, Spittaels K, Haute CV, Checler F, Godaux E, Cordell B, Van Leuven F. Early phenotypic changes in transgenic mice that overexpress different mutations of amyloid precursor protein in brain. J Biol Chem 1999; 274: 6483-92.

Murakami S, Tedesco PM, Cypser JR, Johnson TE. Molecular genetic mechanisms of life span manipulation in Caenorhabditis elegans. Ann N Y Acad Sci 2000; 908: 40-9.

Palapattu GS, Bao S, Kumar TR, Matzuk MM. Transgenic mouse models for tumor suppressor genes. Cancer Detect Prev 1998; 22: 75-86.

Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL. Extension of Drosophila life span by overexpression of human SOD1 in motorneurons. Nat Genet 1999; 19: 171-4.

Rogina B, Reenan RA, Nilsen SP, Helfand SL. Extended life-span conferred by cotransporter gene mutations in drosophila. Science 2000; 290: 2137-40.

Ross RE. Age-specific decrease in aerobic efficiency associated with increase in oxygen free radical production in Drosophila melanogaster. J Insect Physiol 2000; 46: 1477-1480.

Roth GS, Ingram DK, Black A, Lane MA. Effects of reduced energy intake on the biology of aging: the primate model. Eur J Clin Nutr 2000; 54: S15-20.

Sasaki T, Fujiwara H. Detection and distribution of telomerase activity in insects. Eur J Biochem 2000; 267: 3025-31.

Sun J, Tower J. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Moll Cell Biol 1999; 19: 216-28.

Utsugi T, Ohno T, Ohyama Y, Uchiyama T, Saito Y, Matsumura Y, Aizawa H, Itoh H, Kurabayashi M, Kawazu S, Tomono S, Oka Y, Suga T, Kuro-o M, Nabeshima Y, Nagai R. Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. Metabolism 2000; 49: 1118-23.

Vanfleteren JR, Braeckman BP. Mechanisms of life span determination in Caenorhabditis elegans. Neurobiol Aging 1999; 20: 487-502.

van Leuven F. Single and multiple transgenic mice as models for Alzheimer's disease. Prog Neurobiol 2000; 61: 305-12.

van Weerden WM, Romjin JC. Use of nude mouse xenograft models in prostate cancer research. Prostate 2000; 43: 263-71.

Wicky C, Villeneuve AM, Lauper N, Codourey L, Tobler H, Muller F. Telomeric repeats (TTAGGC)n are sufficient for chromosome capping function in Caenorhabditis elegans. Proc Natl Acad Sci U S A 1996; 93: 8983-8.

Yasuda K, Adachi H, Fujiwara Y, Ishii N. Protein carbonyl accumulation in aging dauer formation-defective (daf) mutants of Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 1999; 54: B52-3.

Zainal TA, Oberley TD, Allison DB, Szweda LI, Weindruch R. Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J 2000; 14: 1825-36.

Zhu Y, Richardson JA, Parada LF, Graff JM. Smad3 mutant mice develop metastatic colorectal cancer. Cell 1998; 94: 703-14.



 
 
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