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Are there genes that can help us live longer?
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References
 


1- Morris JZ, Tissenbaum HA, Ruvkun GA. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 1996; 382: 536.

2- Kimura KK, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 1997; 277: 942.

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8- Zhou T, Edwards CK, Mountz JD. Prevention of age-related T-cell apoptosis defect in CD-2-fas-transgenic mice. J Exp Med 1995; 182: 129-37.

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11- Martin, op cit.

12- Rünger TM, Bauer C, Dekant B, Möller K, Sobotta P, Czerny C, Poot M, Martin GM. Hypermutable ligation of plasmid DNA ends in cells from patients with Werner syndrome. J Investig Dermatol 1994; 102: 45-8.

13- Schachter F, Faure-Delanef L, Guenot F, Rouger H, Froguel P, Lesueur-Ginot L, Cohen D. Genetic associations with human longevity at the APOE and ACE loci. Nature Genet 1994; 6: 29-32.

14- Rothschild H, Jazwinski SM. Human longevity determinant genes. J La State Med Soc 1998: 150: 272-4.

15- Schachter, op cit.

16- Bowman ED, Bromeke B, Lensing W, Shields PG. Apolipoprotein E allelic frequency in elderly smokers. Am J Med Genet 1998; 76: 32-6.

17- Togo AV, Suspitsin EN, Grigoriev MY, Ilyushik ES, Karpova MB, Hanson KP, Imyanitov EN. L-myc polymorphism in cancer patients, healthy blood donors and elderly, tumor-free individuals in Russia. Int J Cancer 2000; 85: 747-50.

18- Edelmann W, Yang K, Kuraguchi M, Heyer J, Lia M, Kneitz B, Fan K, Brown AM, Lipkin M, Kucherlapati R. Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice. Cancer Res 1999; 59: 1301-7.

19- Terry RD, Katzman R, Bick KL, eds. Alzheimer Disease (Raven Press, New York; 1994).

20- Chiang AN, Chang CP, Chou YC, Huang KY, Hu HH. Differential distribution of apolipoprotein E in young rats and aged spontaneously hypertensive and stroke-prone rats. J Hypertens 1999; 17: 793-800.

21- Popa-Wagner A, Schroder E, Schmoll E, Walker LC, Kessler C. Upregulation of MAP1B and MAP2 in the rat brain after middle cerebral artery occlusion: effect of age. J Cereb Blood Flow Metab 1999; 19: 425-34.

22- Carmelli D, Swan GE, Reed T, Schellenberg GD, Christian JC. The effect of apolipoprotein E epsilon4 in the relationships of smoking and drinking to cognitive function. Neuroepidemiology 1999; 18: 125-33.

23- Dufouil C, Tzourio C, Brayne C, Berr C, Amouyel P, Alperovitch A. Influence of apolipoprotein E genotype on the risk of cognitive deterioration in moderate drinkers and smokers. Epidemiology 2000; 11: 280-4.

24- Souied EH, Benlian P, Amouyel P, Feingold J, Lagarde JP, Munnich A, Kaplan J, Coscas G, Soubrane G. The epsilon4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration. Am J Ophthalmol 1998; 125: 353-9.

25- Salamone LM, Cauley JA, Zmuda J, Pasagian-Macauley A, Epstein RS, Ferrell RE, Black DM, Kuller LH. Apolipoprotein E gene polymorphism and bone loss: estrogen status modifies the influence of apolipoprotein E on bone loss. J Bone Miner Res 2000; 15: 308-14.

26- Schachter, op cit.

27- Ibid.

28- Takata H, Suzuki M, Ishii T, Sekiguchi S, Iri H. Influence of major histocompatibility complex region genes on human longevity among Okinawan-Japanese centenarians and nonagenarians. Lancet 1987; 2: 824-6.

29- Mannucci PM, Mari D, Merati G, Peyvandi F, Taglibue L, Sacchi E, Taioli E, Sansoni P, Bertolini S, Francheschi C. Gene polymorphism predicting high plasma levels of coagulation and fibrinolysis proteins. A study in centenarians. Arterioscler Thromb Vasc Biol 1997; 17: 755-9.

30- Perls TT, Bubrick E, Wager CG, Vijg J, Kruglyak L. Siblings of centenarians live longer. Lancet 1998; 351: 1560.

31- Perls TT, Silver MH. Living to 100: Lessons in Living to Your Maximum Potential at any Age. New York, Basic Books, 1999.

32- McGue M, Vaupel JW, Holm N, Harvald B. Longevity is moderately heritable in a sample of Danish twins born 1870-1880. J Gerontol 1993; 48: B237-B244.

33- Barzilai N, in press.

34- Hsueh WC, Mitchell BD, Schneider JL, Wagner MJ, Bell CJ, Nanthakumar E, Shuldiner AR. QTL influencing blood pressure maps to the region of PPH1 on chromosome 2q31-34 in Old Order Amish. Circulation 2000; 101: 2810-6.


 
 
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